Volume 28, Issue 29, Pages 4539-4686 (23 June 2010)
A cost–effectiveness analysis of Japanese encephalitis vaccine in Cambodia
Sok Touch, Chutima Suraratdecha, Chham Samnang, Seng Heng, Lauren Gazley, Chea Huch, Ly Sovann, Chab Seak Chhay, Sann Chan Soeung
This study aimed to evaluate the cost and effectiveness of introducing a live, attenuated vaccine (SA 14-14-2) against Japanese encephalitis (JE) into the immunization program. The study demonstrated that SA 14-14-2 immunization is cost–effective in controlling JE in Cambodia compared to no vaccination. Averting one disability-adjusted life year, from a societal perspective, through the introduction of SA 14-14-2 through routine immunization, or a combination of routine immunization plus a campaign targeting children 1–5 or 1–10 years of age, costs US$22, US$34 and US$53, respectively. Sensitivity analyses confirmed that there was a high probability of SA 14-14-2 immunization being cost–effective under conditions of uncertainty.